Born in Hamrun, Azzopardi completed a Teacher Training Course (1952) and some time after she joined the British Institute Players and started a career as actress.
She used to write scripts and take part in programmes for school children broadcasting on the Redifussion. In the sixties she went to London and took an intensive course at the Actors studio. The Maltese Government also sent her on a BBC Course and on her return she took part in several important productions (always in leading roles). In 1960 she won the Best actress Trophy in theatrical competition hosted by the Malta Drama League. In 1965 she won the Manoel Theatre Award. She also won the Redifussion Gold star twice as best radio play actress. In 1974, with the help of other personalities she established Atturi Theatre Group. She has played many leading roles and took part in several television productions, cultural programmes, interviews, discussions and also Maltese tele-seriels. Azzopardi is a great lover of Maltese Literature, is often seen reading poems during literature programmes. She was the co-foundress of Unjoni Nazzjonali tad-Drama and for two years Chairperson of the Federation of Companies and Kumpanija Atturi Productions. For 6 years she was a member of the Government Censors Board and judge of festivals and works for radio and stage.
In 1998 she accompanied her husband, Chev. Paul Naudi who was appointed Ambassador of Malta, to Moscow. Back in Malta she is once again very active in the field of acting.