Anthony J. Mamo was born in Birkirkara on 8 January 1909 from Joseph Mamo and Carla Brincat. Educated at the Archibishop’s Seminary and later at the Royal University of Malta where, in 1931, he graduated as Bachelor of Arts (B.A) and in 1934, as Doctor of Laws (LL.D). As the first student in the course he was awarded the Government "Travelling Scholarship" and the "Bugeja Scholarship". He had short courses at London University and University of Perugia.
In October 1936 he was appointed member of the Commission which, under the chairmanship of Judge Harding, was entrusted with the task of preparing a Revised Edition of all the Laws of Malta.
During the Second World War he gave his services for refugee work and general service.
In 1942 Dr Mamo entered the Attorney-General's Office as one of the Crown Counsel. Here he occupied in succession all the grades (1950-52 – Senior Crow Counsel), until he himself became Attorney-General in 1955.
In the same period, from 1943 to 1957 he became Professor of Criminal Law at the University of Malta where for many here he was member of the Senate and President of the University Council.
Anthony Mamo served as chief legal adviser under 4 Prime Ministers: Sir Paul Boffa, Dr Enrico Mizzi, Dr Gorg Borg Olivier, Dominic Mintoff. and he accompanied all Ministerial delegations for discussions and negotiations with the British Government.
From 1957 to 1971 he was appointed as Chief Justice and president of the Court Appeal.
Towards the end of June 1962, Acting Governor pending the arrival of the new British governor, Sir Maurice Dorman.
In 1964 he was the First President of the Constitutional Court and in 1967 the First President of the Court of Criminal Appeals.
From 1971 to 1974, he was appointed as the first Maltese Governor-General.
When Malta was proclaimed a Republic in 1974, he was elected by the Parliament as the first President of Malta (13th December1974 - 26th December 1976).

Honors:
1955 – Officer of the Order of the British Empire (Commonwealth Honors).
1957 – Honorary Queen’s Counsel (Commonwealth Honors).
1960 - Knight Bachelor
1962 – Knight of Grace of the Venerable Order of St John.
06 April 1990 – Companion of Honor of the National Order of Merit by right as a former President of Malta.