António Manoel de Vilhena, 28 May 1663 – 10 December 1736, was a Portuguese nobleman who was the 66th Prince and Grand Master of the Order of St. John of Jerusalem from 19 June 1722 to his death in 1736. Unlike a number of the other Grand Masters, he was benevolent and popular with the Maltese people. Vilhena is mostly remembered for the founding of Floriana, the construction of Fort Manoel and the Manoel Theatre, and the renovation of the city of Mdina.