In the initial part of the interview, Frank Mifsud shares memories of his childhood and family. His career in the civil service started in the late 1960s as a clerk at the General Post Office. From there, he moved to several departments and grades in Public Administration, reaching one of the highest possible positions, that of Permanent Secretary within the Health Ministry. He was involved in the task of migration from St Luke’s Hospital to Mater Dei Hospital. Other important areas he worked in were the setting up of MCAST, which included negotiations with the Unions. However, the setting up of SEDQA remains his "most important task". He spoke about several changes which he experienced in Public Administration, mainly the changes brought about by Malta’s membership in the European Union.

In the second part of the interview, Mifsud spoke about the changes brought about by Malta's newfound membership of the European Union. These mainly consisted of new standards which the civil service needed to implement. He also mentioned general changes which he experienced throughout his career, such as the introduction of computers. He also spoke about his role as Permanent Secretary and his relationship with various Prime Ministers.