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The Office of the Prime Minister (OPM) has been based at the Auberge de Castille in Valletta since the 6th of March 1972, playing a central role in decision-making apart from being the administrative headquarters of the government of Malta.

The OPM's mission is to support the prime minister in providing leadership and direction for a stable and effective government. The core departments of OPM include the Cabinet Secretariat, the Management and Personnel Office and the Department of Information.